Precision Elastin-Mimetic Electrospun Scaffolds for Aortic Root Reconstruction: Toward Regenerative, In-Situ Tissue Engineering

Abstract

Reconstruction of the aortic root demands materials that endure complex cyclic loading while preserving native hemodynamics. Current prosthetic and biologic conduits restore patency but do not recapitulate the elastin-dependent compliance and fatigue resistance intrinsic to the aortic root, contributing to valve dysfunction, progressive dilation, and long-term failure. Elastin-mimetic electrospun scaffolds—combining elastin-like polypeptides (ELPs) or elastin-based recombinamers with structural biodegradable polymers such as polycaprolactone (PCL)—offer a rational path toward in-situ regeneration: immediate mechanical support, surface cues for endothelialization, and a degradative timetable that permits host extracellular matrix deposition. Here we synthesize current elastin and vascular tissue engineering literature, define quantitative design targets for aortic-root scaffolds, delineate a preclinical testing pipeline, and map regulatory considerations required for clinical translation. We present two tables that map design levers to mechanical/biologic criteria and preclinical endpoints with recommended assays and sample sizes. This Perspective aims to provide a concise, actionable roadmap for investigators and translational teams pursuing regenerative, elastin-mimetic solutions for aortic root reconstruction.