Ionic Microdomains as Emerging Determinants of Compensatory Nephron Hypertrophy: A Paradigm Shift in Renal Cellular Signaling

Authors

DOI:

https://doi.org/10.63501/w0pjbn38

Keywords:

Ionic Microdomains, Compensatory Nephron Hypertrophy, Renal Cellular Signaling‎, mTOR‎, MAPK

Author Biographies

  • Karan Chaman Lal, Liaquat University of Medical & Health Sciences

    Department of Medicine

  • Ayesha Ubaid Ullah‎, Islamic International Medical College‎

    Department of Medicine

  • Mishal Iqbal, Islamic International Medical College‎

    Department of Medicine

  • Zainab Binte Tahir, Islamic International Medical College‎

    Department of Medicine

  • Jepal Kumar, Liaquat University of Medical & Health Sciences

    Department of Medicine

References

‎1.‎ McArdle Z, Schreuder MF, Moritz KM, Denton KM, Singh RR. Physiology ‎and Pathophysiology of Compensatory Adaptations of a Solitary Functioning Kidney. ‎Front Physiol [Internet]. 2020 Jun 26 [cited 2025 Oct 28];11:725. Available from: ‎https://pmc.ncbi.nlm.nih.gov/articles/PMC7332829/‎

‎2.‎ Al-Awqati Q. Kidney growth and hypertrophy: the role of mTOR and vesicle ‎trafficking. J Clin Invest [Internet]. 2015 Jun 1 [cited 2025 Oct 28];125(6):2267. ‎Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4497766/‎

‎3.‎ Kikuchi H, Chou CL, Yang CR, Chen L, Jung HJ, Park E, et al. Signaling mechanisms ‎in renal compensatory hypertrophy revealed by multi-omics. Nat Commun [Internet]. ‎‎2023 Dec 1 [cited 2025 Oct 28];14(1). Available from: ‎https://pubmed.ncbi.nlm.nih.gov/37328470/‎

‎4.‎ Tanaka S, Fujio Y, Nakayama H. Caveolae-specific CaMKII signaling in the regulation ‎of voltage-dependent calcium channel and cardiac hypertrophy. Front Physiol [Internet]. ‎‎2018 Aug 7 [cited 2025 Oct 28];9(AUG):391436. Available from: ‎https://doi.org/10.1080/15548627.2015.1052208‎

‎5.‎ Ning B, Guo C, Kong A, Li K, Xie Y, Shi H, et al. Calcium Signaling Mediates Cell ‎Death and Crosstalk with Autophagy in Kidney Disease. Cells 2021, Vol 10, Page 3204 ‎‎[Internet]. 2021 Nov 17 [cited 2025 Oct 28];10(11):3204. Available from: ‎https://www.mdpi.com/2073-4409/10/11/3204/htm‎

‎6.‎ Chen JK, Nagai K, Chen J, Plieth D, Hino M, Xu J, et al. Phosphatidylinositol 3-kinase ‎signaling determines kidney size. J Clin Invest [Internet]. 2015 Jun 1 [cited 2025 Oct ‎‎28];125(6):2429–44. Available from: https://pubmed.ncbi.nlm.nih.gov/25985273/‎

‎7.‎ Denic A, Alexander MP, Kaushik V, Lerman LO, Lieske JC, Stegall MD, et al. ‎Detection and Clinical Patterns of Nephron Hypertrophy and Nephrosclerosis Among ‎Apparently Healthy Adults. Am J Kidney Dis [Internet]. 2016 Jul 1 [cited 2025 Oct ‎‎28];68(1):58. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4921258/‎

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Published

2026-03-24

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⁠Letters to the Editor

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