Fatherhood Begins Before Conception - How Epigenetics Is Rewriting the Story of Paternal Inheritance
DOI:
https://doi.org/10.63501/j7k7hj32Keywords:
Epigenetics, Genetic, Spermatozoa, Preconception Care, LifestyleReferences
Amann, R. P. (2008). The cycle of the seminiferous epithelium in humans: A need to revisit? Journal of Andrology, 29(5), 469–487. https://doi.org/10.2164/jandrol.107.004655
Braun, J. M., Messerlian, C., & Hauser, R. (2017). Fathers matter: Why it's time to consider the impact of paternal environmental exposures on children's health. Current Epidemiology Reports, 4(1), 46–55. https://doi.org/10.1007/s40471-017-0098-8
Chen, Q., Yan, M., Cao, Z., Li, X., Zhang, Y., Shi, J., Feng, G., Peng, H., Zhang, X., Zhang, Y., Qian, J., Duan, E., Zhai, Q., & Zhou, Q. (2016). Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science, 351(6271), 397–400. https://doi.org/10.1126/science.aad7977
Donkin, I., & Barrès, R. (2018). Sperm epigenetics and influence of environmental factors. Molecular Metabolism, 14, 1–11. https://doi.org/10.1016/j.molmet.2018.02.006
Feinberg, A. P. (2018). The key role of epigenetics in human disease prevention and mitigation. New England Journal of Medicine, 378(14), 1323–1334. https://doi.org/10.1056/NEJMra1402513
Fullston, T., Ohlsson Teague, E. M. C., Palmer, N. O., DeBlasio, M. J., Mitchell, M., Corbett, M., Print, C. G., Owens, J. A., & Lane, M. (2013). Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content. FASEB Journal, 27(10), 4226–4243. https://doi.org/10.1096/fj.12-224048
Heard, E., & Martienssen, R. A. (2014). Transgenerational epigenetic inheritance: Myths and mechanisms. Cell, 157(1), 95–109. https://doi.org/10.1016/j.cell.2014.02.045
Jenkins, T. G., & Carrell, D. T. (2012). The sperm epigenome and potential implications for the developing embryo. Reproduction, 143(6), 727–734. https://doi.org/10.1530/REP-11-0450
Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., & Morris, M. J. (2010). Chronic high-fat diet in fathers’ programs β-cell dysfunction in female rat offspring. Nature, 467(7318), 963–966. https://doi.org/10.1038/nature09491
Pembrey, M. E., Bygren, L. O., Kaati, G., Edvinsson, S., Northstone, K., Sjöström, M., & Golding, J. (2006). Sex-specific, male-line transgenerational responses in humans. European Journal of Human Genetics, 14(2), 159–166. https://doi.org/10.1038/sj.ejhg.5201538
Rodgers, A. B., Morgan, C. P., Bronson, S. L., Revello, S., & Bale, T. L. (2013). Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation. Journal of Neuroscience, 33(21), 9003–9012. https://doi.org/10.1523/JNEUROSCI.0914-13.2013
Soubry, A. (2018). POHaD: Why we should study future fathers. Environmental Epigenetics, 4(2), dvy007. https://doi.org/10.1093/eep/dvy007
Soubry, A., Schildkraut, J. M., Murtha, A., Wang, F., Huang, Z., Bernal, A., Kurber, J., Jirtle, R. L., Murphy, S. K., & Hoyo, C. (2013). Paternal obesity is associated with IGF2 hypomethylation in newborns: Results from a Newborn Epigenetics Study (NEST) cohort. BMC Medicine, 11, 29. https://doi.org/10.1186/1741-7015-11-29
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