Exploitation of Opioids in America: A Narrative Review of Multidisciplinary Studies.
DOI:
https://doi.org/10.63501/46rhrp66Keywords:
opioids, opioid receptor, pain, fentanyl, OxyContin, overdose, policies, healthAbstract
Opioids continue to ravage many socioeconomically disadvantaged communities across the nation of America. Opioids are pain relievers, but may become harmful when consumption is not regulated. Many overdose on this drug, and may commit actions that entirely change their life’s trajectory for the worse. In this narrative review, information is presented from different sources on what has caused the opioid epidemic, the policies and initiatives that have been established to manage opioid overconsumption, and the sequence of events that occur internally when opioids are consumed. The main purpose of this review is to present the different factors that contribute to gradual opioid addiction, and how those addictions are counteracted. In terms of policies and initiatives, two of them were the Controlled Substances Act and the National Pain Strategy. Both policies were created to attempt to regulate the complex relationship between pain and opioid abuse. Without educational programs such as the Centers of Excellence for Pain Education teaching about opioids, and willingness to attempt nonopioid treatments for pain like methadone, the 13-25 year age range will be susceptible to the damages that opioid overdose can cause.
References
Alam, A., & Juurlink, D. N. (2016, January). The prescription opioid epidemic: An overview for anesthesiologists. ProQuest. https://www.proquest.com/openview/5148fe93d74af4f2f0fce538f87d68eb/1?pq-origsite=gscholar&cbl=326357
Bowra, A., Perez-Brumer, A., Forman, L., & Kohler, J. C. (2024). Interconnected influence: Unraveling Purdue pharmaceutical’s role in the global response to the opioid crisis. International Journal of Drug Policy, 133, 104604. https://doi.org/10.1016/j.drugpo.2024.104604
Center for Drug Evaluation & Research. (2023, March 14). Assessing the impact of opioid overdose and opioid antagonist dosing to support medical product development. U.S. Food and Drug Administration. https://www.fda.gov/drugs/regulatory-science-action/assessing-impact-opioid-overdose-and-opioid-antagonist-dosing-support-medical-product-development
Csete, J. (2019). Criminal justice barriers to treatment of opioid use disorders in the United States: The need for public health advocacy - PMC. American Journal of Public Health, 109(3). https://doi.org/10.2105/AJPH.2018.304852
Dasgupta, N., Beletsky, L., & Ciccarone, D. (2018). Opioid crisis: No easy fix to its social and economic determinants - PMC. American Journal of Public Health, 108(2). https://doi.org/10.2105/AJPH.2017.304187
Gross, J., & Gordon, D. B. (2018). The strengths and weaknesses of current US policy to address pain - PMC. American Journal of Public Health, 109(1). https://doi.org/10.2105/AJPH.2018.304746
Han, Y., Yan, W., Zheng, Y., Khan, M. Z., Yuan, K., & Lu, L. (2019). The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies. Translational Psychiatry, 9(1). https://doi.org/10.1038/s41398-019-0625-0
O’Donnell, J. K., Halpin, J., Mattson, C. L., Goldberger, B. A., & Gladden, R. M. (2017). Deaths involving fentanyl, fentanyl analogs, and U-47700 ... MMWR. Morbidity and Mortality Weekly Report, 66. https://doi.org/10.15585/mmwr.mm6643e1
Rui, P., Santo, L., & Ashman, J. J. (2020). Trends in Opioids Prescribed at Discharge From Emergency Departments Among Adults: United States, 2006–2017. National Health Statistics Reports, 135.
Shulman, M., Wai, J. M., & Nunes, E. V. (2019). Buprenorphine treatment for opioid use disorder: An overview - PMC. CNS Drugs, 33(6). https://doi.org/10.1007/s40263-019-00637-z
Sim, S. K. (1973). Methadone - PMC. Canadian Medical Association Journal, 109(7).
Skolnick, P. (2022). Treatment of overdose in the synthetic opioid era. Pharmacology & Therapeutics, 233, 108019. https://doi.org/10.1016/j.pharmthera.2021.108019
Valentino, R. J., & Volkow, N. D. (2018). Untangling the complexity of opioid receptor function - PMC. Neuropsychopharmacology, 43(13). https://doi.org/10.1038/s41386-018-0225-3
van Draanen, J., Tsang, C., Mitra, S., Karamouzian, M., & Richardson, L. (2020). Socioeconomic marginalization and opioid-related overdose: A systematic review. Drug and Alcohol Dependence, 214, 108127. https://doi.org/10.1016/j.drugalcdep.2020.108127
Van Zee, A. (2009). The promotion and marketing of OxyContin: Commercial triumph, public health tragedy. American Journal of Public Health, 99(2), 221–227. https://doi.org/10.2105/ajph.2007.131714